|
1 / 1
|
DeCS
|
|
 |
|
Descriptor English:
|
|
Kelch-Like ECH-Associated Protein 1
|
|
Descriptor Spanish:
|
|
Proteína 1 Asociada A ECH Tipo Kelch
|
|
Descriptor Portuguese:
|
|
Proteína 1 Associada a ECH Semelhante a Kelch
|
|
Synonyms English:
|
|
KEAP 1 Protein
KEAP-1 Protein
KEAP1 Protein
Kelch Like ECH Associated Protein 1
|
|
Tree Number:
|
|
D12.644.360.024.306
D12.776.157.057.067
D12.776.476.024.387
|
|
Definition English:
|
|
An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS. |
|
History Note English:
|
|
2017
|
|
Allowable Qualifiers English:
|
|
|
|
Record Number:
|
|
56536
|
|
Unique Identifier:
|
|
D000072019
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS
|